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Caboplat (150mg / 450mg) - Carboplatin Injuction

Caboplat (150mg / 450mg) - Carboplatin Injuction

Caboplat contains Carboplatin, a platinum-based chemotherapy drug used to treat a variety of cancers, including ovarian, lung, head and neck, and brain tumors. It works by interfering with the DNA replication process, ultimately destroying cancer cells.

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Description Product Details
General Information:
Generic Name: Carboplatin
Brand Name: Caboplat
Packing: Vial
Strengths Available: 150mg / 450mg
Manufacturer: Delarc Pharmaceuticals
Form: Injection (Concentrated solution for IV use)
Category: Antineoplastic Agent / Alkylating Agent / Platinum Compound
Prescription Status: Prescription-only (Rx)
Product Introduction:
Caboplat is an anti-cancer injection formulated with Carboplatin, commonly used when patients are unable to tolerate cisplatin due to its lower nephrotoxicity. Manufactured under strict pharmaceutical standards, it is a critical part of many chemotherapeutic regimens for solid tumors.
Uses:
Caboplat is indicated for the treatment of:
  1. Ovarian cancer (initial and advanced stages)
  2. Non-small cell lung cancer (NSCLC)
  3. Small cell lung cancer (SCLC)
  4. Head and neck cancers
  5. Brain tumors (including glioblastoma)
  6. Bladder cancer and cervical cancer (off-label in some cases)
Storage Instructions:
  1. Store below 25°C
  2. Do not freeze
  3. Keep the vial in the outer carton to protect from light
  4. Use diluted solution immediately or within the specified stability period under sterile conditions
How It Works (Mechanism of Action):
Caboplat (Carboplatin) is a platinum-based alkylating agent that forms DNA cross-links. These cross-links prevent the proper replication and transcription of DNA, leading to apoptosis (cell death) in rapidly dividing cancer cells.
Side Effects:
Common side effects include:
  1. Nausea and vomiting
  2. Low blood cell counts (anemia, neutropenia, thrombocytopenia)
  3. Fatigue
  4. Loss of appetite
  5. Taste changes
Serious side effects may include:
  1. Kidney function impairment (less severe than cisplatin)
  2. Ototoxicity (hearing loss)
  3. Severe bone marrow suppression
  4. Allergic reactions (rash, itching, breathing difficulty)
  5. Electrolyte imbalances
Dosage (Typical Recommended Dose):
  1. The dosage is usually calculated based on AUC (Area Under Curve) and glomerular filtration rate (GFR) using the Calvert formula
  2. A common dosing example: AUC 5–7.5 mg/mL per minute on Day 1 every 3–4 weeks
  3. Must be administered by an oncology specialist in a clinical setting
Method of Administration:
  1. Administered as an intravenous (IV) infusion over 15–60 minutes
  2. Must be diluted with 5% Dextrose or 0.9% Sodium Chloride
  3. Infusion protocols vary by cancer type and regimen
Precautions:
  1. Use caution in patients with renal impairment—dose adjustments required
  2. Monitor complete blood counts (CBC) before and during treatment
  3. Avoid in pregnancy and breastfeeding
  4. Premedication may be required to reduce nausea/vomiting
  5. Evaluate hearing in pediatric or elderly patients
Drug Interactions:
  1. Increased toxicity with other nephrotoxic drugs (e.g., aminoglycosides, vancomycin)
  2. Avoid live vaccines during treatment
  3. Risk of enhanced myelosuppression when used with other chemotherapeutic agents
Allergies:
  1. Contraindicated in patients with a history of hypersensitivity to Carboplatin or Cisplatin
  2. Monitor for signs of hypersensitivity reactions during infusion (rash, fever, hypotension)
Overdose Information:
  1. Overdose can lead to profound bone marrow suppression, nephrotoxicity, and ototoxicity
  2. No specific antidote—supportive care and hospital monitoring essential
  3. May require transfusion or growth factors in severe marrow suppression
Missed Dose Instructions:
  1. If a dose is missed, consult your oncologist immediately
  2. Do not self-administer or reschedule without medical supervision
  3. Resume according to the doctor’s re-evaluation
Additional Notes:
  1. Carboplatin has a more favorable toxicity profile than cisplatin, especially for renal and gastrointestinal effects
  2. Regular monitoring of renal function, electrolytes, and blood counts is crucial
  3. Thrombocytopenia may be dose-limiting toxicity in some patients
  4. Only for use by trained healthcare professionals in oncology settings

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