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Carbotero (150mg / 450mg) - Carboplatin Injection

Carbotero (150mg / 450mg) - Carboplatin Injection

Carbotero is an intravenous chemotherapy injection containing Carboplatin, used in the treatment of various types of cancers such as ovarian, lung, and brain cancers. It is a platinum-based agent that works by interfering with the DNA of cancer cells, preventing their replication and spread.

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Description Product Details
General Information:
Generic Name: Carboplatin
Brand Name: Carbotero
Packing: Vial
Strengths Available: 150mg / 450mg
Manufacturer: Hetero Healthcare Ltd.
Form: Injection (intravenous)
Category: Antineoplastic / Alkylating Agent (Platinum derivative)
Prescription Status: Prescription-only (Rx)
Product Introduction:
Carbotero is a sterile injectable formulation of Carboplatin, a platinum-containing chemotherapeutic agent. It is widely used either as a monotherapy or in combination with other chemotherapy drugs. Its efficacy and relatively favorable toxicity profile compared to cisplatin make it a commonly prescribed drug in oncology.
Uses:
Carbotero is used in the treatment of:
  1. Ovarian cancer (first-line and recurrent)
  2. Non-small cell lung cancer (NSCLC)
  3. Small cell lung cancer (SCLC)
  4. Head and neck cancers
  5. Brain tumors (e.g., gliomas, off-label)
  6. Testicular and bladder cancers (off-label use)
Storage Instructions:
  1. Store at 2°C–8°C (refrigerated).
  2. Protect from light and do not freeze.
  3. Keep in original packaging until use.
  4. Discard any unused solution after preparation.
How It Works (Mechanism of Action):
Carboplatin is a platinum-based alkylating agent. It forms DNA cross-links which interfere with DNA replication and transcription. This results in apoptosis (cell death) of rapidly dividing cancer cells. It is less nephrotoxic and emetogenic than cisplatin.
Side Effects:
Common side effects:
  1. Nausea and vomiting
  2. Fatigue
  3. Loss of appetite
  4. Temporary hair loss
  5. Electrolyte imbalance
  6. Changes in kidney function
Severe side effects:
  1. Bone marrow suppression (anemia, leukopenia, thrombocytopenia)
  2. Risk of serious infections
  3. Ototoxicity (hearing problems)
  4. Hypersensitivity reactions
  5. Nephrotoxicity (less common than with cisplatin)
Dosage (Typical Recommended Dose):
  1. Adults (ovarian cancer): 300–360 mg/m² IV once every 4 weeks OR
  2. Dose based on AUC (Area Under Curve): 5–7.5 AUC using Calvert Formula:
    Dose (mg) = Target AUC × (GFR + 25)
  3. Dose adjustment may be required based on renal function and hematologic status.
Method of Administration:
  1. Administered via intravenous infusion over 15–60 minutes.
  2. Should be diluted in 5% dextrose or 0.9% sodium chloride before administration.
  3. Administer under the supervision of a qualified healthcare professional.
Precautions:
  1. Regular blood count monitoring is essential before and during treatment.
  2. Use with caution in patients with renal impairment.
  3. Avoid during pregnancy and breastfeeding.
  4. Adequate hydration may help reduce kidney-related side effects.
  5. Pre-medicate in patients with prior hypersensitivity to platinum agents.
Drug Interactions:
  1. Nephrotoxic drugs (e.g., aminoglycosides) may increase renal toxicity.
  2. Myelosuppressive agents increase risk of bone marrow suppression.
  3. Live vaccines should be avoided during treatment due to immunosuppression.
  4. Concurrent use with furosemide may increase ototoxicity.
Allergies:
  1. Contraindicated in patients with hypersensitivity to Carboplatin, cisplatin, or other platinum compounds.
  2. Watch for signs of allergic reaction: rash, itching, dizziness, breathing difficulty.
  3. Discontinue immediately if hypersensitivity occurs.
Overdose Information:
  1. Symptoms include severe myelosuppression, renal toxicity, and electrolyte disturbances.
  2. No specific antidote; treatment is supportive and symptomatic.
  3. Hospitalization and close monitoring are required in case of overdose.
Missed Dose Instructions:
  1. As it is administered in a clinical setting, missed doses are generally rescheduled by the oncologist.
  2. Never self-administer or change the dosing schedule without medical advice.
Additional Notes:
  1. Baseline and ongoing CBC, renal, and liver function tests are recommended.
  2. Patients should avoid crowded places and contact with sick individuals due to lowered immunity.
  3. Effective contraception is advised during and for several months after treatment.
  4. Inform your doctor about all medications and supplements before starting therapy.

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