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Ciszest (10mg / 50mg) - Clsplatin Injection

Ciszest (10mg / 50mg) - Clsplatin Injection

Ciszest contains cisplatin, a platinum-based chemotherapy drug used to treat various cancers, including testicular, ovarian, bladder, and lung cancers. It works by damaging the DNA in cancer cells, preventing them from multiplying.

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Description Product Details
General Information:
Generic Name: Cisplatin
Brand Name: Ciszest
Packing: Vial
Strengths Available: 10mg / 50mg
Manufacturer: Zee Laboratories Ltd
Form: Injection (solution)
Category: Antineoplastic (Alkylating-like agent, Platinum compound)
Prescription Status: Prescription only (Rx)
Product Introduction:
Ciszest is a sterile solution of cisplatin, used intravenously as part of cancer treatment regimens. It is classified as an alkylating-like agent and is typically used in combination with other chemotherapeutic agents.
Uses:
Ciszest is indicated for the treatment of:
  1. Testicular cancer
  2. Ovarian cancer
  3. Bladder cancer
  4. Non-small cell and small cell lung cancer
  5. Head and neck cancers
  6. Cervical cancer
  7. Esophageal and gastric cancers (off-label uses in some protocols)
Storage Instructions:
  1. Store below 25°C
  2. Protect from light and moisture
  3. Do not freeze
  4. Use only clear, particle-free solution
How It Works (Mechanism of Action):
Cisplatin is a platinum coordination complex that forms cross-links between and within DNA strands. This prevents DNA replication and transcription, triggering apoptosis (programmed cell death) in rapidly dividing tumor cells. It is considered cell-cycle nonspecific.
Side Effects:
Common side effects:
  1. Nausea and vomiting (highly emetogenic)
  2. Loss of appetite
  3. Fatigue
  4. Low blood counts (anemia, neutropenia, thrombocytopenia)
  5. Metallic taste in mouth
Severe side effects:
  1. Nephrotoxicity (kidney damage)
  2. Ototoxicity (hearing loss, tinnitus)
  3. Peripheral neuropathy
  4. Electrolyte imbalances (hypomagnesemia, hypokalemia)
  5. Anaphylactic reactions (rare)
Dosage (Typical Recommended Dose):
  1. For testicular cancer: 20 mg/m² IV daily for 5 days (as part of BEP regimen)
  2. For ovarian cancer: 75–100 mg/m² IV every 3–4 weeks
  3. Dosage varies based on cancer type, treatment protocol, and patient factors
Always administered under supervision of a trained oncologist.
Method of Administration:
  1. Intravenous infusion only
  2. Diluted in 0.9% sodium chloride (not compatible with dextrose-containing solutions)
  3. Hydration before and after administration is crucial to reduce kidney toxicity
  4. Anti-emetic premedication is strongly recommended
Precautions:
  1. Ensure adequate kidney function before and during treatment
  2. Monitor electrolytes (Mg, K, Ca) and hearing regularly
  3. Avoid use in patients with severe renal impairment or pre-existing hearing loss
  4. Use caution in elderly patients and those with bone marrow suppression
  5. Avoid pregnancy and breastfeeding during treatment
Drug Interactions:
  1. Increased nephrotoxicity with aminoglycosides, amphotericin B, and NSAIDs
  2. Enhanced ototoxicity when combined with loop diuretics
  3. Can reduce effectiveness of live vaccines
  4. May increase toxicity of cyclosporine
Allergies:
  1. Do not use in patients with known hypersensitivity to cisplatin or platinum compounds
  2. Hypersensitivity reactions can include rash, bronchospasm, hypotension, and anaphylaxis
Overdose Information:
  1. Overdose may lead to severe kidney damage, bone marrow suppression, ototoxicity, and death
  2. No specific antidote exists
  3. Treatment is supportive and symptomatic, including dialysis if needed
  4. Immediate hospitalization and medical intervention are critical
Missed Dose Instructions:
  1. Cisplatin is given under medical supervision on a schedule
  2. If a dose is missed due to side effects or other factors, your oncologist will adjust the regimen
  3. Never self-administer or attempt to make up a missed dose without guidance
Additional Notes:
  1. Cisplatin is a highly emetogenic drug—anti-nausea medications are usually prescribed
  2. Patients should report signs of hearing loss, vision changes, or reduced urination immediately
  3. Blood, kidney, and hearing tests are routinely done during treatment
  4. Hydration protocols (pre and post) are essential to minimize nephrotoxicity

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